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Monday, August 10, 2020 | History

2 edition of Development of a temperature and pH responsive membrane system for regulated drug release found in the catalog.

Development of a temperature and pH responsive membrane system for regulated drug release

Frank Yam

Development of a temperature and pH responsive membrane system for regulated drug release

by Frank Yam

  • 62 Want to read
  • 27 Currently reading

Published .
Written in English


The Physical Object
Pagination1 v., 88 leaves
Number of Pages88
ID Numbers
Open LibraryOL19551023M
ISBN 10061246153X

To evaluate the pH-dependent release behavior of the loaded Ag + ions from the PDA coated GNRs, the Ag [email protected] were diluted in PB each under different pH values (pH = and ) at 37 °C in darkness for predetermined time points, and with laser irradiation at pH for the specific time points (0, 10 min, 1 and 4 h). Paul Inge Dahl / Energy Procedia 00 () planar and tubular membrane manufacturing. These materials include the Ruddlesden-Popper phases (e.g. La2NiO) and perovskite oxides (e.g. CaTi Fe O 3). Additionally, efforts are directed towards further development of selected membrane.

Mechanisms of temperature compensation in membranes: importance of fatty acids and membrane physical state Heat and membrane other perturbations reset the temperature threshold of heat shock response Figure 1. A Mild Temperature Rise Generates a Transient Signal Depending on the Temperatures of Growth and Induction. (A) Specific GUS activity measured daily in HSP-GUS plants grown at 22°C for 3 d and then exposed continuously, during 7 d, to 22°C (closed squares), 30°C (closed triangles), or 32°C (closed circles) or exposed to seven daily cycles of 1 h at 30°C (22/30°C, open triangles.

  Stimuli-responsive polymers can be engineered, in both film and colloid forms, to respond to a variety of inputs, from temperature to pH. The inherent flexibility in their structure and responses. Dual stimuli responsive hollow nanogels with IPN structure for temperature controlling drug loading and pH triggering drug release Z. Xing, C. Wang, J. Yan, L. Zhang, L. Li .


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Development of a temperature and pH responsive membrane system for regulated drug release by Frank Yam Download PDF EPUB FB2

Development of a Temperature and pH Responsive Membrane System for Regulated Drug Release Master of Science, Frank Yam Graduate Department of Pharmaceutid Sciences, University of Toronto ABSTRACT The purpose of the study is to develop a temperature and pH responsive membrane system that releases an increased amount of drug with inçreasing temperature, orAuthor: Frank Yam.

Stimuli-sensitive drug delivery is a promising strategy for achieving on-demand release of drugs. External and internal stimuli, including temperature, pH, ultrasound, and specific molecules (e.g., glucose), can all be utilized to regulate the release of drugs in various delivery systems.[] Among them, temperature has been commonly used as a stimulus to trigger drug release due to the fact Cited by: Membrane-Coated Tablets: A System for the Controlled Release of Drugs GÃran Källstrand, Bo Ekmanx Pharmaceutical Research and Development, AR Ferrosan, S 80 MalmÃ, Sweden.

Pharmaceutical Research and Development AR Ferrosan, S 80 Malmà Sweden Abstract Membrane-coated tablets were developed to provide a dosage form which Cited by: The release of a model drug, 4-acetamidophen, was dependent on the temperature which determined the swelling status of the PNIPAAm hydrogel microparticles in the microchannels of the membrane.

A similar approach was used to develop a reservoir type microcapsule drug delivery system by encapsulating the drug core with ethylcellulose containing Cited by: Thermo- and pH-responsive polymers in drug delivery discussed in this paper, deal with pH-responsive drug delivery system.

Thermo-responsive polymer is also covered to a large a polymer to become membrane active at a specific temperature [28] and/or a specific pH [29].In. Self-regulated DDS This type of FR-DDS depends on a reversible and competitive binding mechanism to activate and to regulate the release of drug.

In this system the drug reservoir is a drug complex encapsulated in a impermeable polymeric membrane. The release of drug from the delivery system is activated by the membrane permeation of a.

Work with biodegradable polymers has also yielded polyorthoesters that are pH sensitive and that will degrade more quickly in acidic environments.

3 Such polymers have been studied as the central core of a drug delivery system in which the polymer-insulin matrix is surrounded by a membrane containing grafted glucose oxidase, which provides the. The release behavior of CHL from the hydrogels β-CD-AA indicated that the release ratio of CHL is affected by the pH value, and the cumulative release at pH = was higher than that at pH = The rate of drug release is dependent on the thickness of the coating membrane, levels of leachable pore-forming agents, the amount of soluble components incorporated in the coating, drug solubility within the tablet core and the osmotic pressure differences across the membrane, but unaffected by pH and gastrointestinal motility (20–22).

In the past decade, polymersomes (also referred to as polymeric vesicles) have attracted rapidly growing interest based on their intriguing aggregation phenomena, cell and virus-mimicking dimensions and functions, as well as tremendous potential applications in medicine, pharmacy, and biotechnology.

Unlike liposomes self-assembled from low molecular weight lipids, polymersomes are in general. Feedback regulated drug delivery system 32 Feedback regulated drug delivery system• In this system release of drug molecule from delivery system activated by a triggering agent.

33 Feedback regulated DDS is classified as follow sion regulated DDS. ponsive DDS. regulated DDS. In this review, recent progresses in the drug release systems based on stimuli-responsive polymers are summarized, in which drugs can be released in an intelligent mode with high accuracy and.

With the continued development of controlled-release technology, the need has arisen for materials with more specific drug-delivery properties.

These materials include ionic or water-soluble polymers, with both hydrophilic and hydrophobic characteristics, that respond to external physical (pH, redox, heat, etc) and chemical (glucose) signals [1]. Drug release is facilitated under acidic conditions as protonated PMAA disrupts the electrostatic interaction between DOX and the hydrogel (pH.

We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA).

We have shown that drug release from the. increasing momentum especially in the fields of controlled and self-regulated drug delivery. Stimuli-responsive or “smart“ polymers are macromolecules that display a significant physiochemical change in response to small changes in their environment such as temperature, pH.

Temperature-responsive polymers or thermoresponsive polymers are polymers that exhibit a drastic and discontinuous change of their physical properties with temperature. The term is commonly used when the property concerned is solubility in a given solvent, but it may also be used when other properties are responsive polymers belong to the class of stimuli-responsive materials.

Where Q t is the cumulative mass of drug release per unit release area at time t, C * w is the solubility of the drug in the release medium, P is the time dependent permeability, A is the drug loading, L is the half thickness of the matrix, and Q inf is the drug loading per unit release area.

This model had the advantage of being able to. CC Ng, Y-L Cheng, BA Saville. Thermoresponsive polymer membrane for the local delivery of drugs. J Sex Reprod Med ;1(1) OBJECTIVE: To develop a temperature-responsive polymer membrane that is permeable to drug only at temperatures above 42”C.

A triggerable implant that releases drug only when heated can be made by encapsulating a. This revealed that our developed pH-responsive porous polymer-coated MNs could potentially be used for the controlled release of drug formulations in an acidic environment.

Moreover, the stimuli-responsive drug carriers will enable on-demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity. The concentration a drug must reach in the tissues that respond to the particular drug to cause the desired therapeutic effect Enzyme Induction Process by which the presence of a chemical that is bio-transformed by a particular enzyme system in the liver causes increased activity of that enzyme system.White Paper: Nature Reviews Drug Discovery Vol 9, p.

Basic Introduction and Summary of Transporter Highlights what we know Methods for Studying Transporters Current solutions and future prospects Drug Development Issues Decision trees. Membrane Transporters in Drug Development. The International Transporter Consortium, ITC.Start studying ptcb.

Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. across cell membranes into the circulatory system of the body is known as: absorption. new drug initial development new drug clinical trials new drug post approval trials.

new drug initial development consists of.